Sugiura T, Kodaka T, Nakane S, Kishimoto S, Kondo S, Waku K
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Biochem Biophys Res Commun. 1998 Feb 24;243(3):838-43. doi: 10.1006/bbrc.1998.8187.
Human vascular endothelial cells were found to generate and release 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, upon stimulation with thrombin or A23187. We confirmed that vascular smooth muscle cells as well as endothelial cells possess cannabinoid CB1 receptor mRNA. 2-Arachidonoylglycerol, generated in vascular tissues, may play an important role in modulating vascular tone through acting on the cannabinoid CB1 receptor expressed on vascular smooth muscle cells, endothelial cells as well as peripheral nerve terminals.
研究发现，人血管内皮细胞在受到凝血酶或A23187刺激后，会生成并释放内源性大麻素受体配体2-花生四烯酸甘油酯。我们证实，血管平滑肌细胞和内皮细胞均含有大麻素CB1受体mRNA。在血管组织中生成的2-花生四烯酸甘油酯，可能通过作用于血管平滑肌细胞、内皮细胞以及外周神经末梢上表达的大麻素CB1受体，在调节血管张力方面发挥重要作用。
