真菌中的细胞色素P450酶系统。
Cytochrome P450 enzyme systems in fungi.
作者信息
van den Brink H M, van Gorcom R F, van den Hondel C A, Punt P J
机构信息
Department of Molecular Genetics and Gene Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
出版信息
Fungal Genet Biol. 1998 Feb;23(1):1-17. doi: 10.1006/fgbi.1997.1021.
The involvement of cytochrome P450 enzymes in many complex fungal bioconversion processes has been characterized in recent years. Accordingly, there is now considerable scientific interest in fungal cytochrome P450 enzyme systems. In contrast to S. cerevisiae, where surprisingly few P450 genes have been identified, biochemical data suggest that many fungi possess numerous P450 genes. This review summarizes the current information pertaining to these fungal cytochrome P450 systems, with emphasis on the molecular genetics. The use of molecular techniques to improve cytochrome P450 activities in fungi is also discussed.
近年来，细胞色素P450酶在许多复杂的真菌生物转化过程中的参与情况已得到表征。因此，目前科学界对真菌细胞色素P450酶系统有着浓厚的兴趣。与酿酒酵母不同，在酿酒酵母中令人惊讶地只鉴定出了很少的P450基因，生化数据表明许多真菌拥有众多的P450基因。本综述总结了有关这些真菌细胞色素P450系统的当前信息，重点是分子遗传学。还讨论了利用分子技术提高真菌中细胞色素P450活性的情况。
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