Fontaine P
Service d'Endocrinologie et de Diabétologie, Clinique Marc Linquette CHRU, Lille, France.
Therapie. 1997 Sep-Oct;52(5):461-71.
The high prevalence rate of mortality in diabetic patients is explained by atherothrombotic cardiovascular disease. Hyperinsulinemia and insulin resistance, dyslipidemia, chronic hyperglycemia, decrease of endothelial cells and of monocytes-macrophage cell functions, and hypercoagulability are the main side-effects which are involved in the pathogenesis of diabetic atherothrombotic disease. Its clinical manifestations are coronary heart disease, peripheral vascular insufficiency, cerebral vascular insufficiency and reno-vascular hypertension. The common characteristics are a clinical latent period, the frequency of acute complications and the widespread bilateral distal localisation of vascular insufficiency. The therapeutic strategy in diabetic atherothrombotic disease is becoming better codified, leading to screening and prevention. The evaluation of diabetic vascular risk could reduce the prevalence of thrombotic events.
糖尿病患者的高死亡率是由动脉粥样硬化血栓形成性心血管疾病导致的。高胰岛素血症和胰岛素抵抗、血脂异常、慢性高血糖、内皮细胞及单核细胞 - 巨噬细胞功能减退以及高凝状态是参与糖尿病动脉粥样硬化血栓形成性疾病发病机制的主要副作用。其临床表现为冠心病、外周血管功能不全、脑血管功能不全和肾血管性高血压。共同特点是临床潜伏期、急性并发症的发生率以及血管功能不全广泛双侧远端定位。糖尿病动脉粥样硬化血栓形成性疾病的治疗策略正日益规范，从而实现筛查和预防。对糖尿病血管风险的评估可降低血栓形成事件的发生率。
