Cohen-Solal A, Logeart D, Seknadji P
Service de cardiologie hôpital Beaujon, Clichy.
Rev Prat. 1997 Dec 1;47(19):2109-13.
Heart failure is defined as the inability of the heart to deliver a cardiac output sufficient for the needs of the periphery. The mechanisms responsible for ventricular failure always correspond for changes in ventricular filling that may have 2 origins: decrease in ventricular systolic function, leading the ventricle to operate on the vertical part of its pressure volume relationship; primary decrease in ventricular distensibility. An increase neurohormonal stimulation participates in sodium retention and in the preservation of blood pressure. The mechanisms leading to the progressive alteration of the haemodynamic status are not perfectly known, but a progressive increase in wall stress and myocyte loss are likely to occur.
心力衰竭的定义为心脏无法输出足以满足外周需求的心输出量。导致心室衰竭的机制总是与心室充盈的变化相对应，心室充盈变化可能有两个起源：心室收缩功能下降，导致心室在其压力-容积关系的垂直部分运行；心室扩张性原发性降低。神经激素刺激增加参与钠潴留和血压维持。导致血流动力学状态逐渐改变的机制尚不完全清楚，但壁应力可能会逐渐增加，心肌细胞可能会逐渐丢失。
