Ferrer I, Martí E
Unitat de Neuropatología, Servei d'Anatomía Patològica, Hospital Princeps d'Espanya, Barcelona, Spain.
Neurosci Lett. 1998 Jan 16;240(3):139-42. doi: 10.1016/s0304-3940(97)00948-8.
To learn about the localization of fibroblast growth factor (FGF) ligands in normal and pathologic brains, fibroblast growth factor receptor-1 (FGFR-1; Flg) and FGFR-3 immunoreactivities were examined in the hippocampus of patients with Alzheimer's disease and age-matched controls. Flg immunoreactivity was found in practically all neurons of the hippocampus and dentate gyrus in control and Alzheimer's disease cases. In patients with Alzheimer's disease, Flg immunoreactivity was present in tangle-bearing and non-tangle-bearing neurons, as well as in neurons with granulovacuolar degeneration, but not in ghost tangles. Aberrant neurites of senile plaques were negative. FGFR-3 immunoreactivity was found in reactive glial cells, most of them astrocytes, including those in the vicinity of senile plaques.
为了解成纤维细胞生长因子（FGF）配体在正常和病理大脑中的定位，我们检测了阿尔茨海默病患者及年龄匹配对照组海马体中的成纤维细胞生长因子受体-1（FGFR-1；Flg）和FGFR-3免疫反应性。在对照组和阿尔茨海默病患者中，几乎海马体和齿状回的所有神经元均发现有Flg免疫反应性。在阿尔茨海默病患者中，Flg免疫反应性存在于有神经原纤维缠结和无神经原纤维缠结的神经元中，以及有颗粒空泡变性的神经元中，但在幽灵缠结中未发现。老年斑的异常神经突呈阴性。FGFR-3免疫反应性在反应性胶质细胞中发现，其中大多数是星形胶质细胞，包括老年斑附近的星形胶质细胞。
