Sharma T, Badrinath S S, Gopal L, Ravishankar K, Shanmugam M P, Bhende P, Bhende M, Shetty N S, Deshpande D A, Mukesh B N
Medical and Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Retina. 1998;18(1):23-9. doi: 10.1097/00006982-199801000-00005.
To report the rare occurrence of subretinal fibrosis in patients with multifocal central serous chorioretinopathy and evaluate the role of systemic corticosteroids and the effects of laser photocoagulation on multifocal leaks.
A total of 29 patients (mean age, 37.7 years; 89.7% male) treated for subretinal fibrosis and multifocal central serous chorioretinopathy from 1983-1995 were reviewed retrospectively. Mean follow up was 26 months (range, 6.8-81 months).
Retinal detachment involved the macula in 72.4% cases. Fluorescein angiography showed a mean of 6.7 (range, 2-22) central serous chorioretinopathy leaks and a mean of 1.8 (range, 1-5) retinal pigment epithelial detachments. The fundus pictures of 23 patients who were taking systemic corticosteroids showed no improvement. Following laser treatment, however, retinal reattachment was obtained in all eyes, and improvement in visual acuity of > 2 Snellen lines was noted in 68.9% of patients.
The presence of subretinal fibrosis with secondary retinal detachment in otherwise healthy young patients, particularly in men, should alert the physician to look for multifocal central serous retinopathy leaks. Systemic corticosteroids did not prove effective in treating these patients, although laser treatment is recommended for each leak identified on an angiogram.
报告多灶性中心性浆液性脉络膜视网膜病变患者中罕见的视网膜下纤维化情况,并评估全身用皮质类固醇的作用以及激光光凝对多灶性渗漏的影响。
回顾性分析了1983年至1995年间因视网膜下纤维化和多灶性中心性浆液性脉络膜视网膜病变接受治疗的29例患者(平均年龄37.7岁;89.7%为男性)。平均随访时间为26个月(范围6.8 - 81个月)。
72.4%的病例视网膜脱离累及黄斑。荧光素血管造影显示平均有6.7个(范围2 - 22个)中心性浆液性脉络膜视网膜病变渗漏,平均有1.8个(范围1 - 5个)视网膜色素上皮脱离。23例正在服用全身用皮质类固醇的患者眼底照片无改善。然而,激光治疗后,所有患眼均实现视网膜复位,68.9%的患者视力提高超过2行。
在原本健康的年轻患者,尤其是男性患者中出现伴有继发性视网膜脱离的视网膜下纤维化,应提醒医生寻找多灶性中心性浆液性视网膜病变渗漏。全身用皮质类固醇治疗这些患者未证明有效,尽管建议对血管造影中发现的每个渗漏进行激光治疗。