Hellinga H W
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Fold Des. 1998;3(1):R1-8. doi: 10.1016/S1359-0278(98)00001-7.
Metalloprotein properties result from the interplay between coordination requirements of the metal center, protein stability, and modulation of the metal center by the surrounding protein matrix. Simple metal centers, which exercise control over the protein by affecting stability or enzyme activity, have been created by rational design. Complex centers, which require control by the protein matrix, have also been constructed.
金属蛋白的性质源于金属中心的配位需求、蛋白质稳定性以及周围蛋白质基质对金属中心的调节之间的相互作用。通过合理设计已构建出简单的金属中心，其通过影响稳定性或酶活性来对蛋白质进行调控。也构建出了需要蛋白质基质调控的复杂中心。
