Devaraj S, Jialal I
Center for Human Nutrition, Department of Pathology, The University of Texas Southwestern Medical Center at Dallas 75235-9072, USA.
Curr Opin Lipidol. 1998 Feb;9(1):11-5. doi: 10.1097/00041433-199802000-00004.
Low levels of alpha tocopherol have been associated with increased risk for coronary artery disease and increased intake has been shown to be protective. Data support a proatherogenic role for oxidized LDL in atherosclerosis and several studies show that alpha tocopherol decreases the susceptibility of LDL to oxidation. In addition, alpha tocopherol can partition in the artery wall in critical cells such as smooth muscle cells, monocyte-macrophages, endothelial cells, and platelets, exerting beneficial effects. In this review, the anti-atherogenic effects of alpha tocopherol on crucial cells in atherogenesis have been highlighted, such as the inhibition of smooth muscle cell proliferation, preservation of endothelial function, inhibition of monocyte-endothelial adhesion, inhibition of monocyte reactive oxygen species and cytokine release, and inhibition of platelet adhesion and aggregation.
低水平的α-生育酚与冠状动脉疾病风险增加相关，而摄入增加已显示具有保护作用。数据支持氧化型低密度脂蛋白在动脉粥样硬化中具有促动脉粥样硬化作用，多项研究表明α-生育酚可降低低密度脂蛋白的氧化敏感性。此外，α-生育酚可在动脉壁的关键细胞如平滑肌细胞、单核细胞-巨噬细胞、内皮细胞和血小板中分布，发挥有益作用。在本综述中，强调了α-生育酚对动脉粥样硬化形成过程中关键细胞的抗动脉粥样硬化作用，如抑制平滑肌细胞增殖、维持内皮功能、抑制单核细胞与内皮细胞的黏附、抑制单核细胞活性氧和细胞因子释放以及抑制血小板黏附和聚集。
