Faculty of Medicine, University of Chile, Santiago, Chile.
Molecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
Redox Rep. 2021 Dec;26(1):35-44. doi: 10.1080/13510002.2021.1891808.
The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress could be an unavoidable effect derived even from the surgical procedure itself.
A systematic review was performed following an electronic search of Pubmed and ScienceDirect databases. Keywords such as sepsis, oxidative stress, organ dysfunction, antioxidants, outcomes in postoperative complications, among others, were used. Review articles were preferably used between the years 2015 onwards, not excluding older ones.
The vast majority point to the role of oxidative stress in generating greater damage and worse prognosis in postoperative patients without the necessary care and precautions, taking importance on the use of antioxidants to prevent this problem.
Oxidative stress represents a common final pathway related to pathological processes such as inflammation or ischemia-reperfusion, among others. The expression of greater severity of these complications can result in multiple organ dysfunction or sepsis. The aim of this study was to present an update of the role of oxidative stress on surgical postoperative complications.
手术后的损伤程度是多年来研究的课题。许多手术并发症会影响患者的术后生活质量，甚至导致死亡。尽管这些并发症通常是多因素机制引起的，但氧化应激起着关键的病理生理作用。此外，氧化应激甚至可能是手术本身不可避免的影响。
通过对 Pubmed 和 ScienceDirect 数据库进行电子检索，进行了系统评价。使用了诸如败血症、氧化应激、器官功能障碍、抗氧化剂、术后并发症结果等关键词。综述文章最好是在 2015 年以后发表的，也不排除更早的文章。
绝大多数研究表明，在没有必要的护理和预防措施的情况下，氧化应激会导致术后患者产生更大的损伤和更差的预后，重视抗氧化剂的使用以预防这个问题。
氧化应激是与炎症或缺血再灌注等病理过程相关的常见终末途径。这些并发症的严重程度增加可能导致多器官功能障碍或败血症。本研究旨在介绍氧化应激在外科手术后并发症中的作用的最新进展。
