Bouchard C, Daw E W, Rice T, Pérusse L, Gagnon J, Province M A, Leon A S, Rao D C, Skinner J S, Wilmore J H
Physical Activity Sciences Laboratory, Laval University, Ste-foy, Québec, Canada.
Med Sci Sports Exerc. 1998 Feb;30(2):252-8. doi: 10.1097/00005768-199802000-00013.
This study investigates the familial resemblance of maximal oxygen uptake (VO2max) based on data from 86 nuclear families of Caucasian descent participating in the HERITAGE Family Study. In the current study, VO2max was measured twice on a cycle ergometer in 429 sedentary individuals (170 parents and 259 of their offspring), aged between 16 and 65 yr. The VO2max was adjusted by regression procedures for the effects of 1) age and sex; 2) age, sex, and body mass; and 3) age, sex, body mass, fat mass, and fat-free mass, as determined by underwater weighing. Evidence for significant familial resemblance was observed for each of the three VO2max phenotypes. Spouse, sibling, and parent-offspring correlations were significant, suggesting that both genetic and environmental factors contribute to the familial resemblance for VO2max. Maximal heritability estimates were at least 50%, a value inflated to an undetermined degree by nongenetic factors. The hypothesis of maternal inheritance, with the father's contribution being environmental, was also found to fit the data with estimates of maternal heritability, potentially associated in part with mitochondrial inheritance, reaching about 30%. These results suggest that genetic and nongenetic factors as well as maternal influences contribute to the familial aggregation of VO2max in sedentary individuals.
本研究基于参与遗传家庭研究的86个白种人核心家庭的数据，调查了最大摄氧量（VO2max）的家族相似性。在本研究中，对429名久坐不动的个体（170名父母及其259名后代）在自行车测力计上进行了两次VO2max测量，这些个体年龄在16至65岁之间。通过回归程序对VO2max进行了调整，以消除以下因素的影响：1）年龄和性别；2）年龄、性别和体重；3）年龄、性别、体重、脂肪量和去脂体重（通过水下称重确定）。对于三种VO2max表型中的每一种，均观察到显著家族相似性的证据。配偶、兄弟姐妹以及父母与后代之间的相关性均显著，这表明遗传和环境因素均对VO2max的家族相似性有贡献。最大遗传率估计至少为50%，该值因非遗传因素而在一定程度上被夸大。母亲遗传假说（即父亲的贡献为环境因素）也被发现与数据相符，母亲遗传率估计约为30%，这可能部分与线粒体遗传有关。这些结果表明，遗传和非遗传因素以及母亲的影响均对久坐不动个体中VO2max的家族聚集有贡献。
