Saris N E, Karjalainen A, Teplova V V, Lindros K O
Department of Medical Chemistry, University of Helsinki, Finland.
Biochem Mol Biol Int. 1998 Jan;44(1):127-34. doi: 10.1080/15216549800201132.
The effect of alpha-lipoate and dihydrolipoate on the mitochondrial permeability transition was investigated. Both substances promoted the permeability transition in isolated rat liver mitochondria and in permeabilized hepatocytes, dihydrolipoate most potently in spite of it being a dithiol. The stimulation was prevented by Cyclosporin A or hydroxybutyltoluene but not by ascorbate. It is suggested that the greater potency of dihydrolipoate could be due to formation of a radical.
研究了α-硫辛酸和二氢硫辛酸对线粒体通透性转换的影响。两种物质均促进分离的大鼠肝线粒体和透化肝细胞中的通透性转换，尽管二氢硫辛酸是一种二硫醇，但其促进作用最为显著。环孢素A或羟基甲苯可阻止这种刺激，但抗坏血酸不能。提示二氢硫辛酸更强的效力可能是由于自由基的形成。
