Ekong R, Wolfe J
MRC Human Biochemical Genetics Unit, Galton Laboratory, London, UK.
Curr Opin Biotechnol. 1998 Feb;9(1):19-24. doi: 10.1016/s0958-1669(98)80079-7.
Recent advances in fluorescent in situ hybridisation included the generation of allele-specific probes, bar-coded chromosomes, and the visualisation of chromosome territories and genes within the nucleus. One major advance has been our ability to visualise and make precise and reproducible measurements from stretched DNA molecules prepared directly from human cells.
荧光原位杂交技术的最新进展包括等位基因特异性探针、条形码染色体的产生，以及细胞核内染色体区域和基因的可视化。一项重大进展是我们能够对直接从人类细胞制备的拉伸DNA分子进行可视化，并进行精确且可重复的测量。
