Dreyer L, Olsen J H
Division for Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
Epidemiology. 1998 Mar;9(2):178-83.
We studied whether common shared environmental or behavioral risk factors, other than tobacco smoking, underlie both atherosclerotic diseases and cancer. We identified a group of 96,891 one-year survivors of acute myocardial infarct through the Danish Hospital Discharge Register between 1977 and 1989. We calculated the incidence of cancer in this group by linking it to the Danish Cancer Registry for the period 1978-1993. There was no consistent excess over the expected figures for any of the categories of cancer not related to tobacco smoking. Specifically, the rates of colorectal cancer in acute myocardial infarct patients were similar to those of the general population, as were the rates for hormone-related cancers, including endometrial and postmenopausal breast cancers. We found a moderate increase in the risk for tobacco-related cancers, which was strongest for patients with early onset of acute myocardial infarct and for female patients. Overall, there do not seem to be major shared environmental or behavioral risk factors for acute myocardial infarct and cancers, except for smoking, and there seems to be no common inherited susceptibility to the development of these diseases.
我们研究了除吸烟外，是否存在常见的共同环境或行为风险因素，是动脉粥样硬化疾病和癌症的共同病因。我们通过丹麦医院出院登记册，在1977年至1989年间确定了一组96,891名急性心肌梗死一年幸存者。通过将该组与1978 - 1993年期间的丹麦癌症登记册相联系，我们计算了该组中的癌症发病率。对于任何与吸烟无关的癌症类别，均未发现持续超过预期数字的情况。具体而言，急性心肌梗死患者的结直肠癌发病率与普通人群相似，与激素相关癌症（包括子宫内膜癌和绝经后乳腺癌）的发病率也相似。我们发现与烟草相关癌症的风险有适度增加，这在急性心肌梗死发病早的患者和女性患者中最为明显。总体而言，除了吸烟外，急性心肌梗死和癌症似乎不存在主要的共同环境或行为风险因素，并且似乎不存在对这些疾病发展的共同遗传易感性。
