Mahto Subodh Kumar, Sheoran Ankita, Gadpayle Adesh Kisanji, Gupta Kritika, Gupta Pulin Kumar, Chitkara Anubhuti, Agarwal Nagina
Department of Medicine, PGIMER, Dr. RML Hospital, New Delhi, India.
Department of Biochemtry, PGIMER, Dr. RML Hospital, New Delhi, India.
J Family Med Prim Care. 2022 Apr;11(4):1508-1513. doi: 10.4103/jfmpc.jfmpc_989_21. Epub 2022 Mar 18.
Hypertension remains the major preventable cause of cardiovascular disease (CVD). Lipoprotein (a) is seen to be associated with established essential hypertension and contributes to atherogenesis or to thrombogenesis or both.
Correlation between lipoprotein (a) [Lp(a)] and lipid abnormalities in patients with newly detected hypertension and its association with severity of hypertension.
It was a cross-sectional observational study carried out at PGIMER, DR. RML Hospital, New Delhi, India. Estimation of serum Lp (a) and lipid parameters along with routine laboratory investigations were carried out in 100 newly diagnosed cases with hypertension and compared with age and sex matched 50 healthy normotensive controls.
Amongst 100 cases the mean systolic and diastolic blood pressure was 160.68 ± 19.75 mmHg and 84.44 ± 4.32 mmHg respectively. The mean serum Lp (a) in cases was 34.03 ± 7.55 mg/dl as compared to 24.13 ± 4.41 mg/dl in controls (p < 0.0001). 62% of cases as compared to 12% of controls had elevated serum Lp (a) levels. Apart from that, the levels of Lp (a) and lipid parameters increased significantly with higher stage of disease (p < 0.0001). Approximately 8% of cases had left ventricular hypertrophy as compared to 1% of control. Similarly, 18% of cases had Non-alcoholic fatty liver disease as compared to 4% of controls. 5% of cases had retinopathy as compared to nil in controls. 4% of cases had microalbuminuria as compared to nil in controls.
It was observed that newly detected hypertension is associated with major derangements of Lp (a) and lipid parameters. We also concluded that end organ involvement is significantly higher in newly detected hypertensives as compared to normotensive subjects and it was attributed to be due to lipid abnormalities observed in the group.
高血压仍然是心血管疾病（CVD）的主要可预防病因。脂蛋白（a）被认为与已确诊的原发性高血压相关，并促进动脉粥样硬化或血栓形成，或两者兼而有之。
新诊断高血压患者中脂蛋白（a）[Lp（a）]与脂质异常的相关性及其与高血压严重程度的关联。
这是一项在印度新德里PGIMER、RML医院进行的横断面观察性研究。对100例新诊断的高血压病例进行血清Lp（a）和脂质参数的测定以及常规实验室检查，并与年龄和性别匹配的50名健康血压正常对照者进行比较。
100例病例中，平均收缩压和舒张压分别为160.68±19.75 mmHg和84.44±4.32 mmHg。病例组的平均血清Lp（a）为34.03±7.55 mg/dl，而对照组为24.13±4.41 mg/dl（p<0.0001）。62%的病例血清Lp（a）水平升高，而对照组为12%。除此之外，Lp（a）和脂质参数水平随着疾病分期的升高而显著增加（p<0.0001）。约8%的病例有左心室肥厚，而对照组为1%。同样，18%的病例有非酒精性脂肪性肝病，而对照组为4%。5%的病例有视网膜病变，而对照组无。4%的病例有微量白蛋白尿，而对照组无。
观察到新诊断的高血压与Lp（a）和脂质参数的主要紊乱相关。我们还得出结论，与血压正常的受试者相比，新诊断的高血压患者终末器官受累明显更高，这归因于该组观察到的脂质异常。
