Arrigo A P
Laboratoire du Stress Cellulaire, Centre de Génétique Moléculaire et Cellulaire, CNRS UMR-5534, Claude Bernard University, Villeurbanne, France.
Biol Chem. 1998 Jan;379(1):19-26.
Small stress proteins (sHsp) are molecular chaperones whose expression was shown to enhance the survival of mammalian cells exposed to numerous types of injuries that lead to death, including heat shock, oxidative stress as well as treatments with anti-cancerous and apoptosis-inducing agents. Here, a summary of the most recent results concerning the protective activity of this family of proteins against programmed cell death is presented. (1) sHsp enhance the survival of cells exposed to oxidative stress, a phenomenon which is linked to the ability of these proteins to decrease the intracellular level of reactive oxygen species in a glutathione dependent way. (2) sHsp protect against apoptosis mediated by different agents including staurosporine, etoposide and the Fas ligand. (3) An interesting and particular aspect of sHsp concerns their transient expression during the cell division to differentiation transition. In this context, sHsp expression was shown to be essential for preventing differentiating cells from undergoing apoptosis. Small stress proteins appear therefore as novel regulators that interfere with programmed cell death induced by different pathways.
小应激蛋白（sHsp）是分子伴侣，其表达已被证明可提高暴露于多种导致死亡的损伤类型下的哺乳动物细胞的存活率，这些损伤包括热休克、氧化应激以及用抗癌和诱导凋亡剂进行的处理。在此，本文总结了关于该蛋白家族对程序性细胞死亡的保护活性的最新研究结果。（1）小应激蛋白可提高暴露于氧化应激下的细胞的存活率，这一现象与这些蛋白以谷胱甘肽依赖的方式降低细胞内活性氧水平的能力有关。（2）小应激蛋白可保护细胞免受包括星形孢菌素、依托泊苷和Fas配体在内的不同试剂介导的凋亡。（3）小应激蛋白一个有趣且特殊的方面涉及其在细胞分裂向分化转变过程中的瞬时表达。在这种情况下，小应激蛋白的表达已被证明对于防止分化细胞发生凋亡至关重要。因此，小应激蛋白似乎是干扰不同途径诱导的程序性细胞死亡的新型调节因子。
