Dwivedi S, Jauhari R
Department of Medicine, University College of Medical Sciences, Delhi.
Indian Heart J. 1997 Sep-Oct;49(5):507-10.
Effect of Terminalia arjuna on angina pectoris, congestive heart failure and left ventricular mass was studied in patients of myocardial infarction with angina and/or ischaemic cardiomyopathy. Bark stem powder of T. arjuna, 500 mg 8 hourly was administered to 10 patients of postmyocardial infarction angina and two patients of ischaemic cardiomyopathy, in a dose of 500 mg 8 hourly postoperatively, for a period of three months (Group A). These patients were also on conventional treatment comprising of nitrates, aspirin and/or calcium channel blockers. Twelve age-, sex-, body mass index- and ECG-matched patients of postmyocardial infarction angina receiving only conventional treatment served as controls (Group B). Significant reduction in anginal frequency was noted in both groups (3.5 +/- 1.98 to 1.08 + 1.08 per day vs 3.10 + 0.72 to 1.17 + 0.84 per day). However, only Group A patients showed significant improvement in left ventricular ejection fraction (42.25 + 9.96 to 52.67 + 12.32% vs 51.83 + 5.99 to 49.83 + 2.52%) and reduction in left ventricular mass (159.18 + 51.11 to 127.47 + 52.40 gm/m2 vs 159.11 + 38.92 to 160.78 + 54.23 gm/m2) on echocardiography following three months of therapy. Both patients with ischaemic cardiomyopathy showed significant symptomatic relief in coronary heart failure from NYHA class III to NYHA class I. Prolonged administration of T. arjuna did not show any adverse effects on renal, hepatic and haematological parameters. The potential of T. arjuna to improve left ventricular ejection fraction and reduce left ventricular mass in coronary artery disease needs to be harnessed.
在患有心绞痛和/或缺血性心肌病的心肌梗死患者中，研究了诃子对心绞痛、充血性心力衰竭和左心室质量的影响。将10例心肌梗死后心绞痛患者和2例缺血性心肌病患者术后按每8小时500毫克的剂量服用诃子树皮干粉，持续三个月（A组）。这些患者同时接受包括硝酸盐、阿司匹林和/或钙通道阻滞剂在内的常规治疗。12例年龄、性别、体重指数和心电图匹配的心肌梗死后心绞痛患者仅接受常规治疗作为对照（B组）。两组患者的心绞痛发作频率均显著降低（分别从每天3.5±1.98次降至1.08±1.08次和从每天3.10±0.72次降至1.17±0.84次）。然而，仅A组患者在治疗三个月后的超声心动图检查中左心室射血分数显著改善（从42.25±9.96%升至52.67±12.32%，而对照组从51.83±5.99%降至49.83±2.52%），左心室质量降低（从159.18±51.11克/平方米降至127.47±52.40克/平方米，而对照组从159.11±38.92克/平方米升至160.78±54.23克/平方米）。两名缺血性心肌病患者的冠心病心力衰竭症状从纽约心脏协会（NYHA）III级显著缓解至NYHA I级。长期服用诃子对肾脏、肝脏和血液学参数未显示任何不良反应。诃子在改善冠状动脉疾病患者左心室射血分数和降低左心室质量方面的潜力有待进一步开发利用。
