Faroux M J, Theobald S, Pluot M, Patey M, Menzies D
Laboratory of Cytology, Institut Jean Godinot, Reims, France.
Pathol Res Pract. 1997;193(10):705-12. doi: 10.1016/S0344-0338(97)80030-1.
Fine needle aspiration (FNA) of cold thyroid nodules has become the first line diagnostic decision for electing which patients need surgery. In order to improve FNA accuracy, the monoclonal antithyroperoxidase (TPO) antibody (MoAb47) was tested. A total of 554 patients were included in this study and among them, 208 were referred to surgery. The results of FNA compared to the final histological diagnosis revealed a sensitivity and a specificity of 94 and 55% respectively, while the sensitivity and specificity of TPO immunodetection on the same cases reached 98 and 83% respectively. By combining the two methods, the 3 false-negative of FNA and 60% of suspicious cytology corresponding to histological benign lesions were correctly identified by immunocytochemistry. With better results than FNA alone, TPO immunodetection with MoAb47 represents a useful adjunct to conventional cytology for selecting patients for surgery.
甲状腺冷结节的细针穿刺活检（FNA）已成为筛选哪些患者需要手术的一线诊断方法。为提高FNA的准确性，对单克隆抗甲状腺过氧化物酶（TPO）抗体（MoAb47）进行了检测。本研究共纳入554例患者，其中208例接受了手术。FNA结果与最终组织学诊断相比，敏感性和特异性分别为94%和55%，而同一病例的TPO免疫检测敏感性和特异性分别达到98%和83%。通过联合两种方法，免疫细胞化学正确识别了FNA的3例假阴性以及对应组织学良性病变的60%可疑细胞学结果。由于结果优于单独使用FNA，使用MoAb47进行TPO免疫检测是传统细胞学筛选手术患者的有用辅助手段。
