[两性大鼠的碱性羧肽酶活性]
[Basic carboxypeptidase activity in rats of both sexes].
作者信息
Shchetinina N V, Vernigora A N, Gengin M T
机构信息
V.G. Belinsky Penza State Pedagogical University, Penza, Russia.
出版信息
Ukr Biokhim Zh (1978). 1997 May-Jun;69(3):115-8.
The activity of carboxypeptidase (CP) H, the enzyme taking part in neuropeptide formation, and activity of recently described phenylmethylsulfonyl fluoride (PMSF)--inhibiting CP in males and females of white mongrel rats were studied. Minor differences between the CPH activities in brain regions were found in hippocampus. PMSF-inhibited activity of carboxypeptidase was significantly higher in females than in males in pituitary gland, adrenal gland, olfactory bulbus, optic and auditory bills, cerebellum, hippocampus, striatum, cerebral hemispheres and spleen. The CPH activity was 5-fold higher in ovaries than in testicles. PMSF-inhibited CP activity in testicles was 3.7-fold lower than in ovaries. Possible participation of basic CP in determination of sexual differences of some neuropeptide level and protein catabolism is studied.
研究了参与神经肽形成的羧肽酶（CP）H的活性，以及最近描述的苯基甲基磺酰氟（PMSF）对白色杂种大鼠雄性和雌性中CP的抑制活性。在海马体中发现脑区CPH活性存在微小差异。在垂体、肾上腺、嗅球、视神经和听神经、小脑、海马体、纹状体、大脑半球和脾脏中，PMSF抑制的羧肽酶活性在雌性中显著高于雄性。卵巢中的CPH活性比睾丸高5倍。睾丸中PMSF抑制的CP活性比卵巢低3.7倍。研究了碱性CP在某些神经肽水平和蛋白质分解代谢性差异测定中的可能作用。
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