Petrik J, Guella L, Wight D G, Pearson G M, Hinton J, Parker H, Allain J P, Alexander G J
Division of Transfusion Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's NHS Trust, UK.
Gut. 1998 Jan;42(1):103-6. doi: 10.1136/gut.42.1.103.
A novel flavivirus has been described recently and designated hepatitis G virus (HGV). The virus is transmitted by the parenteral route but it is uncertain whether it is associated with chronic liver disease because liver biopsy is difficult to justify in this group.
To examine histological features of liver biopsy in patients infected with hepatitis C virus (HCV) according to the presence or absence of HCV and HGV RNA.
One hundred and thirty one consecutive HCV carriers undergoing staging liver biopsy were studied retrospectively. In each, HCV RNA and HGV RNA were detected by reverse transcription polymerase chain reaction on serum samples collected at the time of biopsy. The presence of each RNA was correlated with histological features blind to the RNA results; individual histological features of inflammation or fibrosis were scored separately.
Nineteen patients were positive for both HGV and HCV RNA in serum, 91 were positive for HCV RNA alone, two were positive for HGV RNA alone, and 19 were negative for both RNA species. Neither age nor sex differed between the groups; a greater proportion of intravenous drug users were HGV RNA positive, but this was not statistically significant. There was no effect of HGV coinfection on the stage of fibrosis or any other histological parameter except steatosis; patients with HCV and HGV RNA had a higher mean score for fat than those patients with HCV RNA alone (p < 0.05).
HGV coinfection has no important effects on histological features in chronic HCV carriers. It is unlikely that HGV infection causes chronic liver disease.
最近发现了一种新型黄病毒，命名为庚型肝炎病毒（HGV）。该病毒通过肠道外途径传播，但它是否与慢性肝病相关尚不确定，因为在这组患者中进行肝活检的理由并不充分。
根据丙型肝炎病毒（HCV）和HGV RNA的有无，检查HCV感染患者肝活检的组织学特征。
回顾性研究了131例接受分期肝活检的连续HCV携带者。对每例患者，在活检时采集的血清样本上通过逆转录聚合酶链反应检测HCV RNA和HGV RNA。每种RNA的存在与对RNA结果不知情的组织学特征相关；分别对炎症或纤维化的个体组织学特征进行评分。
19例患者血清中HGV和HCV RNA均为阳性，91例仅HCV RNA阳性，2例仅HGV RNA阳性，19例两种RNA均为阴性。各组之间年龄和性别无差异；静脉吸毒者中HGV RNA阳性的比例更高，但无统计学意义。除脂肪变性外，HGV合并感染对纤维化分期或任何其他组织学参数均无影响；HCV和HGV RNA阳性的患者脂肪平均评分高于仅HCV RNA阳性的患者（p < 0.05）。
HGV合并感染对慢性HCV携带者的组织学特征无重要影响。HGV感染不太可能导致慢性肝病。
