Diamantis I, Bassetti S, Erb P, Ladewig D, Gyr K, Battegay M
Outpatient Department of Internal Medicine, University of Basel, Switzerland.
J Hepatol. 1997 Apr;26(4):794-7. doi: 10.1016/s0168-8278(97)80244-9.
BACKGROUND/AIMS: The hepatitis G virus is a newly discovered RNA virus which is possibly transmitted parenterally. Hepatitis G virus is associated with acute or chronic hepatitis and may lead to cirrhosis and liver cancer, characteristics shared by the hepatitis C virus. Hepatitis C virus is prevalent in drug users, but the frequency and role of hepatitis G virus is not yet well established.
One hundred and seventeen heavy i.v. drug users were enrolled in a prospective, controlled, randomized study for i.v. administration of heroin and/or methadone. Hepatitis G virus was detected using a hot start polymerase chain reaction followed by an ELISA polymerase chain reaction assay. Hepatitis C virus genotyping was done using the Inno-Lipa strip assay.
Hepatitis G virus infection was detected in 35% (41/117) of the study population and hepatitis C virus infection in 95.7% (112/117). Ninety-seven percent of hepatitis G virus positive patients were coinfected with hepatitis C virus, of whom 75% were infected with hepatitis C virus genotype 3a. This genotype was prevalent in 48.3% of patients infected with hepatitis C virus alone. The presence or absence of hepatitis G virus infection had no influence on chronic hepatitis. Twenty-two percent of patients who started injecting heroin before 1980 and 40% of those who started after 1980 were hepatitis G virus positive. Overall, 16 patients were infected with human immunodeficiency virus, six were coinfected with hepatitis G virus and hepatitis C virus, and 10 only with hepatitis C virus.
Hepatitis G virus infection is highly prevalent in i.v. drug users, but less frequent than hepatitis C virus infection. The fact that all but two patients were coinfected with hepatitis C virus, 75% with one genotype, supports a common route of transmission for both viruses. The course of hepatitis C virus infection is not altered by hepatitis G virus infection.
背景/目的：庚型肝炎病毒是一种新发现的RNA病毒，可能通过肠道外途径传播。庚型肝炎病毒与急性或慢性肝炎相关，可能导致肝硬化和肝癌，这些特征与丙型肝炎病毒相同。丙型肝炎病毒在吸毒者中很普遍，但庚型肝炎病毒的感染率及作用尚未完全明确。
117名重度静脉注射吸毒者参与了一项关于静脉注射海洛因和/或美沙酮的前瞻性、对照、随机研究。采用热启动聚合酶链反应及酶联免疫吸附聚合酶链反应检测庚型肝炎病毒。使用Innogenetics丙型肝炎病毒基因分型试纸条检测丙型肝炎病毒基因分型。
研究人群中35%（41/117）检测出庚型肝炎病毒感染，95.7%（112/117）检测出丙型肝炎病毒感染。97%的庚型肝炎病毒阳性患者同时感染了丙型肝炎病毒，其中75%感染的是丙型肝炎病毒3a基因型。该基因型在仅感染丙型肝炎病毒的患者中占48.3%。庚型肝炎病毒感染与否对慢性肝炎无影响。1980年前开始注射海洛因的患者中22%为庚型肝炎病毒阳性，1980年后开始注射的患者中40%为庚型肝炎病毒阳性。总体而言，16名患者感染了人类免疫缺陷病毒，6名同时感染了庚型肝炎病毒和丙型肝炎病毒，10名仅感染了丙型肝炎病毒。
庚型肝炎病毒感染在静脉注射吸毒者中非常普遍，但比丙型肝炎病毒感染的频率低。除两名患者外所有患者均同时感染丙型肝炎病毒，且75%为同一基因型，这一事实支持两种病毒有共同的传播途径。庚型肝炎病毒感染不会改变丙型肝炎病毒感染的病程。
