MacCalman C D, Getsios S, Chen G T
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
Am J Reprod Immunol. 1998 Feb;39(2):96-107. doi: 10.1111/j.1600-0897.1998.tb00341.x.
The cadherins are a gene superfamily of calcium-dependent cell adhesion molecules. To date, the role(s) of the cadherins in human implantation remains poorly defined.
The spatiotemporal expression of the type 2 cadherins, known as cadherin-11 and cadherin-6, in the endometrium and placenta was examined using the reverse transcriptase-polymerase chain reaction.
Cadherin-6 and cadherin-11 are differentially expressed in the endometrial stroma during the menstrual cycle. The switch between cadherin-6 and cadherin-11 expression in the endometrial stroma occurs during the late secretory phase. Maximum cadherin-11 mRNA levels were observed in the decidua of early pregnancy but were markedly reduced at term. In the placenta, cadherin-11 is expressed in the syncytial trophoblast and extravillous cytotrophoblast columns. However, cadherin-6 seems to be the predominant cadherin subtype present in highly invasive extravillous cytotrophoblasts.
Cadherin-11 and cadherin-6 may play a central role in the formation and organization of the human endometrium and placenta.
钙黏着蛋白是一类钙依赖性细胞黏附分子的基因超家族。迄今为止，钙黏着蛋白在人类着床过程中的作用仍不清楚。
采用逆转录聚合酶链反应检测2型钙黏着蛋白，即钙黏蛋白-11和钙黏蛋白-6，在子宫内膜和胎盘中的时空表达。
在月经周期中，钙黏蛋白-6和钙黏蛋白-11在子宫内膜基质中的表达存在差异。子宫内膜基质中钙黏蛋白-6和钙黏蛋白-11表达的转换发生在分泌晚期。在妊娠早期的蜕膜中观察到钙黏蛋白-11 mRNA水平最高，但在足月时显著降低。在胎盘中，钙黏蛋白-11表达于合体滋养层细胞和绒毛外细胞滋养层柱。然而，钙黏蛋白-6似乎是高侵袭性绒毛外细胞滋养层中存在的主要钙黏蛋白亚型。
钙黏蛋白-11和钙黏蛋白-6可能在人类子宫内膜和胎盘的形成与组织中起核心作用。
