Berne B, Ros A M
Department of Dermatology, University Hospital, Uppsala, Sweden.
Contact Dermatitis. 1998 Feb;38(2):61-4. doi: 10.1111/j.1600-0536.1998.tb05653.x.
Since 1990 7 sunscreen allergens have been included in the standard photopatch protocol at 2 Swedish dermatology clinics. 355 consecutive patients with suspected photosensitivity were tested, and in 28 of these (7.9%), a total of 42 allergic reactions were found. 80% of the reactions were of photocontact origin. The most common allergen was benzophenone-3 (Eusolex 4360), with 15 photocontact and 1 contact allergic reactions, followed by isopropyl dibenzoylmethane (Eusolex 8020) (8 photocontact, 4 contact) and butyl methoxydibenzoylmethane (Parsol 1789), with 6 photocontact reactions. There were 2 cases of photocontact allergy to phenylbenzimidazole sulfonic acid (Eusolex 232), which has not been reported previously. 1 case of contact urticaria from benzophenone-3 was accidentally found. In addition, 21 + reactions of doubtful relevance were noted in 14 patients: 16 on irradiated and 5 on non-irradiated test sites. Among these, irritant and phototoxic reactions may be included. These results indicate that the inclusion of UV filters in the standard photopatch protocol is important. Immediate-type testing for urticaria could also be of value.
自1990年以来，瑞典的2家皮肤科诊所已将7种防晒过敏原纳入标准光斑贴试验方案。对355例疑似光敏性的连续患者进行了检测，其中28例（7.9%）共发现42例过敏反应。80%的反应为光接触性起源。最常见的过敏原是二苯甲酰基甲烷（依索佳4360），有15例光接触过敏和1例接触性过敏反应，其次是二苯甲酰甲烷异丙酯（依索佳8020）（8例光接触过敏，4例接触性过敏）和丁基甲氧基二苯甲酰甲烷（帕索1789），有6例光接触过敏反应。有2例对苯基苯并咪唑磺酸（依索佳232）的光接触过敏，此前未见报道。意外发现1例由二苯甲酰基甲烷引起的接触性荨麻疹。此外，在14例患者中发现21例相关性存疑的反应：16例出现在照射部位，5例出现在未照射部位。其中可能包括刺激性反应和光毒性反应。这些结果表明，在标准光斑贴试验方案中纳入紫外线过滤剂很重要。对荨麻疹进行速发型检测也可能有价值。
