Lien E J, Perrin J H
J Med Chem. 1976 Jun;19(6):849-50. doi: 10.1021/jm00228a025.
The micelle formation tendency (log 1/CMC)) of a series of alkyldimethylbenzylammonium compounds is shown to be linearly dependent on the alky chain length, indicating no curling of the side chain up to C19. Protein binding of these charged molecules on the primary binding site for sulfaethiodole is shown to be parabolically dependent on the chain length with an optimal chain length around C16.
一系列烷基二甲基苄基铵化合物的胶束形成倾向(log 1/CMC)显示出与烷基链长度呈线性相关,这表明在C19之前侧链没有卷曲。这些带电荷分子在磺胺乙噻唑的主要结合位点上的蛋白质结合显示出与链长度呈抛物线关系,最佳链长度约为C16。