奥美拉唑用于治疗对西咪替丁耐药的婴儿消化性食管炎。

Omeprazole in infants with cimetidine-resistant peptic esophagitis.

作者信息

Alliët P, Raes M, Bruneel E, Gillis P

机构信息

Department of Pediatrics, Virga Jesse Hospital, Hasselt, Belgium.

出版信息

J Pediatr. 1998 Feb;132(2):352-4. doi: 10.1016/s0022-3476(98)70460-3.

DOI:10.1016/s0022-3476(98)70460-3

PMID:9506656

Abstract

Twelve neurologically normal infants (age 2.9+/-0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity.

摘要

12名患有消化性食管炎（2级）且对西咪替丁（除体位调整、西沙必利和胃仙-U外）无反应的神经功能正常的婴儿（年龄2.9±0.9个月），接受了奥美拉唑治疗，剂量为0.5mg/kg，每日1次，持续6周。通过治疗前后的临床评估和内镜检查以及7名婴儿治疗期间的24小时胃pH监测，对所有婴儿评估了奥美拉唑的疗效。奥美拉唑治疗使症状、食管炎的内镜和组织学征象以及胃内酸度显著降低。