小鼠肌肉再生：一项体内二维氢磁共振波谱（MRS）研究。
Mouse muscle regeneration: an in vivo 2D 1H magnetic resonance spectroscopy (MRS) study.
作者信息
Gillet B, Lefaucheur J P, Sébille A, Beloeil J C
机构信息
Laboratoire de RMN biologique, ICSN, CNRS, Gif sur Yvette, France.
出版信息
FEBS Lett. 1998 Feb 13;423(1):71-4. doi: 10.1016/s0014-5793(98)00068-4.
Muscle degeneration and regeneration were studied by 2D 1H magnetic resonance spectroscopy (MRS) and histological examination, in an experimental model of muscle injury using a myotoxic snake venom, notexin. The injured muscles produced a very specific MRS signal, corresponding to a tri-unsaturated fatty acid (linolenic acid-like) signal, from day 2 to day 9 after injury. The combination of MRS with histology showed that this signal was associated with a mechanism occurring during myoblast fusion to form myotubes. 2D 1H MRS is thus a useful non-invasive tool for detecting muscle regeneration in vivo.
在使用肌毒性蛇毒——诺维毒素构建的肌肉损伤实验模型中，通过二维¹H磁共振波谱（MRS）和组织学检查对肌肉变性和再生进行了研究。从损伤后第2天到第9天，受损肌肉产生了一个非常特殊的MRS信号，该信号对应于一种三不饱和脂肪酸（类亚麻酸）信号。MRS与组织学相结合的结果表明，这一信号与成肌细胞融合形成肌管过程中发生的一种机制有关。因此，二维¹H MRS是一种用于在体内检测肌肉再生的有用的非侵入性工具。
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