Liu S, Gao J
Department of Neurobiology, Institute of Neuroscience, The Fourth Military Medical University, Xian, China.
Brain Res. 1998 Jan 19;781(1-2):114-20. doi: 10.1016/s0006-8993(97)01227-4.
The anterior pituitary is known to be regulated by hypothalamic hormones via the portal system. However, our recent studies have demonstrated the presence of a substantial amount of substance P (SP)-, calcitonin gene-related peptide (CGRP)- and galanin (GAL)- immunoreactive (ir) nerve fibers with numerous varicosities in the anterior pituitaries of the Macaca mulatta monkey. The present study investigated the relationship of the GAL-ir nerve fibers to the glandular cells. The M. mulatta monkeys were used and sections of the anterior pituitary were double immunostained. GAL-ir nerve fibers and/or varicosities were found in proximity to contact directly with corticotropes, somatotropes, lactotropes, gonadotropes and thyrotropes without any exception. These findings indicate that a direct neural factor may be involved in the regulation of adenohypophyseal secretion.
已知腺垂体通过门脉系统受下丘脑激素的调节。然而，我们最近的研究表明，在恒河猴的腺垂体中存在大量含有P物质（SP）、降钙素基因相关肽（CGRP）和甘丙肽（GAL）免疫反应性（ir）神经纤维，这些神经纤维有许多膨体。本研究调查了GAL免疫反应性神经纤维与腺细胞的关系。使用了恒河猴，并对腺垂体切片进行了双重免疫染色。无一例外，发现GAL免疫反应性神经纤维和/或膨体紧邻促肾上腺皮质激素细胞、生长激素细胞、催乳激素细胞、促性腺激素细胞和促甲状腺激素细胞，并直接与其接触。这些发现表明，直接的神经因素可能参与腺垂体分泌的调节。
