Fiehring H, Assmann I, Haustein K O
Z Gesamte Inn Med. 1979 Oct 15;34(20):suppl 273-6.
On the patients with moderate and severe heart insufficiency haemodynamic, clinical and electrocardiographic examinations were carried out. After the application of digitoxin at the beginning in the majority of cases no favourable effects on clinical and haemodynamic findings could be proved. In 2 patients with cor pulmonale even a drastic deterioration with increase of the pulmonary pressure and formation of a pulmonary oedema developed. The temporary analysis of the systole and the estimation of the glycoside level did not give any reliable references. The recompensation began only after 2-3 days. In 5 out of 10 patients in whom the cardiac rhythm was continuously controlled by means of a tape storage device, after the application of digoxin ventricular extrasystoles appeared. Also in these cases increased as well as subtherapeutic digoxin-plasma levels were present. In 2 patients with hypertrophic obstructive cardiomyopathy the infundibular gradients were considerably increased by strophantin. The causes of the different reaction patters are to be sought in disease-specific peculiarities, in the degree of severity of the heart insufficiency, in the speed of the flooding of glycoside and several extracardiac factors.
对中重度心力衰竭患者进行了血流动力学、临床和心电图检查。在大多数病例中，起初应用洋地黄毒苷后，未证实对临床和血流动力学结果有良好影响。在2例肺心病患者中，甚至出现了肺动脉压升高和肺水肿形成的急剧恶化。对收缩期的临时分析和糖苷水平的评估未提供任何可靠依据。代偿仅在2 - 3天后开始。在10例通过磁带存储装置持续控制心律的患者中，有5例在应用地高辛后出现室性早搏。在这些病例中，地高辛血浆水平也有升高以及低于治疗水平的情况。在2例肥厚性梗阻性心肌病患者中，毒毛花苷使漏斗部梯度显著增加。不同反应模式的原因应从疾病特异性特点、心力衰竭的严重程度、糖苷充盈速度以及几个心外因素中寻找。
