Haustein K O, Assmann I, Fiehring H
Eur J Cardiol. 1980 Feb;11(2):135-46.
The pharmacodynamic effects (changes of systolic time intervals, STI, reaction of pulmonary arterial pressure) of digitoxin were studied in 7 patients with severe congestive heart failure in comparison with the corresponding plasma level. STI indicated glycoside-dependent changes, i.e. shortening of LVETc and QS2c and normalization of prolonged PEPc, while ICT shortening was less observed. In 2 patients with cor pulmonale a pulmonary oedema occurred accompanied with prolonged LVETc. During the early period of glycoside-dependent recompensation no significant correlation between STI shortening and glycoside plasma level was observed. Because of the retarded normalization of the haemodynamics of the pulmonary circulation and because of possible side-effects, rapid digitalization has to be reconsidered.
对7例严重充血性心力衰竭患者，研究了洋地黄毒苷的药效学效应（收缩期时间间期变化、STI、肺动脉压反应），并与相应的血浆水平进行比较。STI显示出糖苷依赖性变化，即LVETc和QS2c缩短，延长的PEPc恢复正常，而ICT缩短较少见。2例肺心病患者发生肺水肿，伴有LVETc延长。在糖苷依赖性代偿早期，未观察到STI缩短与糖苷血浆水平之间有显著相关性。由于肺循环血流动力学恢复正常延迟以及可能的副作用，必须重新考虑快速洋地黄化。
