Bray J P, Burbidge H M
Department of Veterinary Clinical Science, Massey University, Palmerston North, New Zealand.
J Am Anim Hosp Assoc. 1998 Mar-Apr;34(2):135-44. doi: 10.5326/15473317-34-2-135.
In the second of a two-part article on the canine intervertebral disk, the morphological changes which occur within the disk during aging and degeneration are described. Degeneration of the intervertebral disk appears to be a self-perpetuating process as a consequence of disruption to the annulus fibrosus, cellular remodeling, altered biomechanical loading, and nutritional deficiencies. In the nonchondrodystrophoid disk, premature acceleration of the aging process can occur following traumatic disruption to the annulus fibrosus. This degeneration usually occurs in isolated disks along the length of the vertebral column. By contrast, disk degeneration in the chondrodystrophoid breeds occurs simultaneously in all disks along the vertebral column and usually is well advanced by two years of age. Ultrastructural differences between the intervertebral disk of the nonchondrodystrophoid dog and that of the chondrodystrophoid dog may explain the rapidity and severity of degenerative changes in the latter breeds.
在一篇关于犬椎间盘的系列文章的第二篇中，描述了椎间盘在老化和退变过程中发生的形态学变化。椎间盘退变似乎是一个自我延续的过程，这是由于纤维环破裂、细胞重塑、生物力学负荷改变和营养缺乏所致。在非软骨发育不良型椎间盘中，纤维环受到创伤性破坏后，衰老过程会过早加速。这种退变通常发生在脊柱全长的单个椎间盘中。相比之下，软骨发育不良型犬种的椎间盘退变在脊柱全长的所有椎间盘中同时发生，通常在两岁时就已严重退变。非软骨发育不良型犬和软骨发育不良型犬椎间盘的超微结构差异可能解释了后者退变变化的快速性和严重性。
