Ghosh P, Taylor T K, Braund K G, Larsen L H
Vet Pathol. 1976;13(6):414-27. doi: 10.1177/030098587601300603.
The chemical composition of the intervertebral disc of 9-month-old chondrodystrophoid and nonchondrodystrophoid dogs was studied for collagen, noncollagenous protein and glycosaminoglycan. Content of these substances differed significantly between breeds. The differences were most marked in the nucleus pulposus; the noncollagenous protein content of the nonchondrodystrophoid breed was higher than in that of the chondrodystrophoid dogs. The total nitrogen value of the nonchondrodystrophoid nuclei pulposi was less than that of the corresponding chondrodystrophoid discs mainly because of the high collagen content of the latter discs. Histochemically, it was found that the nuclei pulposi of the nonchondrodystrophoid breed contains larger amounts of glycosaminoglycan than in the discs of the chondrodystrophoid breeds.
对9个月大的软骨发育不良和非软骨发育不良犬的椎间盘进行了化学成分研究，分析其中的胶原蛋白、非胶原蛋白和糖胺聚糖。这些物质的含量在不同品种之间存在显著差异。差异在髓核中最为明显；非软骨发育不良品种的非胶原蛋白含量高于软骨发育不良犬。非软骨发育不良髓核的总氮值低于相应的软骨发育不良椎间盘，主要是因为后者椎间盘的胶原蛋白含量较高。组织化学研究发现，非软骨发育不良品种的髓核中糖胺聚糖的含量高于软骨发育不良品种的椎间盘。
