Gürdöl F, Oner-Yyidothan Y, Yalçýn O, Genç S, Buyru F
Department of Biochemistry, Istanbul Faculty of Medicine, Capa, Turkey.
Res Commun Mol Pathol Pharmacol. 1997 Jul;97(1):38-46.
The effects of menopause on antioxidant enzyme activities were investigated in blood and endometrial tissues of women. Endometrial pieces were obtained from pre- or postmenopausal patients who had hysterectomy due to descendus or prolapsus uteri. In endometrium homogenates, both cytosolic superoxide dismutase (CuZn-SOD) and catalase (CAT) activities were similar in pre- or postmenopausal women (median ages 41 and 64, respectively); whereas GPx (glutathione peroxidase) activity was significantly decreased (p < 0.001). Activity of these enzymes were also compared in the blood of premenopausal and late menopausal women, and only GPx activity was found significantly low (p < 0.01). Subsequent measurements were carried out in blood of healthy menopausal women who were in the same age intervals with the premenopausal subjects studied, and GPx activity was found indifferent in two groups, indicating that the decrement is due to aging rather than the change in hormonal status. CuZn-SOD activity was highest in blood of late menopausal group compared with those in both premenopausal and early menopausal group, giving a significant difference with the latter (p < 0.001). In other words, SOD activity was increased in menopausal women at an older age, showing a diverse change with GPx activity.
研究了绝经对女性血液和子宫内膜组织中抗氧化酶活性的影响。子宫内膜组织取自因子宫脱垂或子宫下垂而接受子宫切除术的绝经前或绝经后患者。在子宫内膜匀浆中，绝经前和绝经后女性（中位年龄分别为41岁和64岁）的胞质超氧化物歧化酶（CuZn-SOD）和过氧化氢酶（CAT）活性相似；而谷胱甘肽过氧化物酶（GPx）活性显著降低（p<0.001）。还比较了绝经前和绝经后期女性血液中这些酶的活性，发现只有GPx活性显著降低（p<0.01）。随后对与所研究的绝经前受试者年龄区间相同的健康绝经女性血液进行了测量，发现两组中GPx活性无差异，表明这种降低是由于衰老而非激素状态的变化。与绝经前和绝经早期组相比，绝经后期组血液中的CuZn-SOD活性最高，与后者有显著差异（p<0.001）。换句话说，绝经女性年龄较大时SOD活性增加，与GPx活性呈现不同变化。
