大蒜（蒜）和黑种草籽（黑种草）对健康绝经后女性的抗氧化作用。
Antioxidant effect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women.
作者信息
Mostafa Randa M, Moustafa Yasser M, Mirghani Zien, AlKusayer Ghader M, Moustafa Kareem M
机构信息
Basic Medical Sciences Department, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
出版信息
SAGE Open Med. 2013 Dec 24;1:2050312113517501. doi: 10.1177/2050312113517501. eCollection 2013.
OBJECTIVES
The objective of this study is to investigate the antioxidant effects of garlic extract and crude black seeds' consumption on blood oxidant/antioxidant levels in healthy postmenopausal women.
METHODS
In total, 30 healthy postmenopausal women (mean age = 50.31 ± 4.23 years) participated. They ingested two garlic soft gels per day (each is equivalent to 1000 mg of fresh garlic bulb) and crude black seed grounded to powder in a dose of 3 g/day for 8 weeks. Oxidant (malondialdehyde) activity in plasma and antioxidants superoxide dismutase and glutathione peroxidase activities in erythrocytes were studied.
RESULTS
Significant low levels of plasma malondialdehyde with increased erythrocyte glutathione peroxidase and superoxide dismutase activities.
DISCUSSION
Menopause is associated with an increase in oxidative stress and a decrease in some antioxidant parameters. Consumption of garlic extracts and crude black seeds may have a beneficial effect on improved balance between blood oxidants and antioxidants in healthy postmenopausal women.
目的
本研究旨在调查大蒜提取物和食用黑种草籽对健康绝经后女性血液氧化/抗氧化水平的抗氧化作用。
方法
共有30名健康绝经后女性（平均年龄 = 50.31 ± 4.23岁）参与。她们每天摄入两粒大蒜软胶囊（每粒相当于1000毫克新鲜大蒜鳞茎）和3克/天磨成粉末的黑种草籽，持续8周。研究了血浆中的氧化剂（丙二醛）活性以及红细胞中的抗氧化剂超氧化物歧化酶和谷胱甘肽过氧化物酶活性。
结果
血浆丙二醛水平显著降低，红细胞谷胱甘肽过氧化物酶和超氧化物歧化酶活性增加。
讨论
绝经与氧化应激增加和一些抗氧化参数降低有关。食用大蒜提取物和黑种草籽可能对改善健康绝经后女性血液氧化剂和抗氧化剂之间的平衡有有益作用。
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