Kogan A S, Kolpakov M G, Tsys' O N, Matveev P V, Protsenko M I
Kardiologiia. 1976 May;16(5):76-9.
The study concerns the effect of angiotensin II when infused into the systemic and portal blood flow upon the general and renal haemodynamics in normal dogs and in hypertensive animals, as well as the effect of the operation of porto-caval transposition upon the course of renovascular hypertension. When peptide is infused, at a rate that causes a moderate pressor effect, into the systemic blood flow of normal animals, an antidiuretic and antinatriuretic effect is obtained, in hypertensive animals--an increase of diuresis, natriuresis and a less distinct pressor effect are obtained. When angiotensin II is infused into the portal flow, a less distinct pressor and renal effect is seen in animals with renovascular hypertension. The operation of porto-caval transposition of the vessels results in a hypotensive effect in the animals with renovascular hypertension.
本研究关注向正常犬和高血压动物的体循环血流及门静脉血流中输注血管紧张素 II 对全身和肾脏血流动力学的影响，以及门腔静脉转位手术对肾血管性高血压病程的影响。当以引起中度升压效应的速率向正常动物的体循环血流中输注该肽时，可获得抗利尿和利钠作用，而在高血压动物中，则可使利尿、利钠增加，升压作用不那么明显。当向门静脉血流中输注血管紧张素 II 时，在肾血管性高血压动物中可见到不那么明显的升压和肾脏效应。血管的门腔静脉转位手术对肾血管性高血压动物有降压作用。
