强力脂可泰对高胆固醇喂养家兔的抗动脉粥样硬化作用。

Antiatherosclerotic effect of Lipotab Forte in cholesterol-fed rabbits.

作者信息

Raj kumar S, Pillai K K, Balani D K, Hussain S Z

机构信息

Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, Hamdard Nagar, New Delhi, India.

出版信息

J Ethnopharmacol. 1998 Jan;59(3):125-30. doi: 10.1016/s0378-8741(97)00105-0.

DOI:10.1016/s0378-8741(97)00105-0

PMID:9507895

Abstract

The effect of Lipotab Forte, a new polypharmaceutical herbal formulation developed on the principles of the Unani system of medicine, was investigated on the progression of atherosclerosis in cholesterol fed rabbits. Retardation of the progression of atherosclerosis was observed in animals treated with Lipotah Forte. The results were related to changes in the cholesterol content of aorta from the same animal. Blood cholesterol and triglyceride levels were greatly elevated in all rabbits on cholesterol feeding, but were significantly decreased by Lipotab Forte treatment. Lipotab Forte treatment also lowered aorta Thiobarbituric acid reactive substance (TBARS) levels from 79.72 (+/-5.70) to 24.9 (+/-2.04) nmol/g of wet tissue and reduced hepatic cholesterol significantly in hypercholesterolemic rabbits.

摘要

按照尤纳尼医学体系原则研发的新型复方草药制剂力补佳（Lipotab Forte）对喂饲胆固醇的家兔动脉粥样硬化进展的影响进行了研究。观察到接受力补佳治疗的动物动脉粥样硬化进展减缓。结果与同一动物主动脉胆固醇含量的变化有关。所有喂饲胆固醇的家兔血液胆固醇和甘油三酯水平均大幅升高，但力补佳治疗使其显著降低。力补佳治疗还使高胆固醇血症家兔主动脉硫代巴比妥酸反应物质（TBARS）水平从79.72（±5.70）降至24.9（±2.04）nmol/g湿组织，并显著降低了肝脏胆固醇水平。