Unnikrishnan A G, Singh S K, Sanjeevi C B
Department of Endocrinology, Amrita Institute of Medical Sciences, Cochin, Kerala, India.
Ann N Y Acad Sci. 2004 Dec;1037:118-21. doi: 10.1196/annals.1337.018.
While type 2 diabetic subjects in developed countries are predominantly obese or overweight, those in India are often nonobese or lean. The reasons for leanness in these subjects has not been well understood. We assessed the prevalence of pancreatic islet autoimmunity in 83 lean adult subjects (BMI < 18.5 kg/m(2)) with type 2 diabetes by measuring antibodies to glutamic acid decarboxylase-65 (GAD Abs). Positivity to GAD Ab was present in 21 (25.3%) subjects. In addition, subjects with GAD Ab positivity were younger and had lower beta cell function (homeostasis model assessment, HOMA) as compared to the GAD Ab-negative group. This suggests that the antibody-positive group could have a slowly progressive form of type 1 diabetes.
在发达国家，2型糖尿病患者主要是肥胖或超重的，而在印度，这类患者往往不肥胖或体型偏瘦。这些患者体型偏瘦的原因尚未完全明确。我们通过检测谷氨酸脱羧酶65抗体（GAD抗体），评估了83名体重偏轻的成年2型糖尿病患者（体重指数<18.5kg/m²）中胰岛自身免疫的患病率。21名（25.3%）受试者的GAD抗体呈阳性。此外，与GAD抗体阴性组相比，GAD抗体阳性的受试者年龄更小，β细胞功能（稳态模型评估，HOMA）更低。这表明抗体阳性组可能患有缓慢进展型1型糖尿病。
