Anwar A J, Walker J D, Frier B M
Department of Diabetes, Royal Infirmary of Edinburgh, NHS Trust, UK.
Diabet Med. 1998 Feb;15(2):160-3. doi: 10.1002/(SICI)1096-9136(199802)15:2<160::AID-DIA537>3.0.CO;2-J.
Type 1 insulin-dependent, diabetes mellitus (Type 1 DM) is thought to be more prevalent in individuals with Down's syndrome. To ascertain the local prevalence of Type 1 DM in patients with Down's syndrome in a geographically defined area, the four diabetes clinics in Lothian were surveyed and 13 patients with Down's syndrome and Type 1 DM were identified. Using data from previous epidemiological surveys which determined the prevalence of Down's syndrome in the general population, the prevalence rate of Type 1 DM in patients with Down's syndrome was calculated to be between 1.4 and 10.6%, a prevalence considerably higher than in the general population. Although 7 (54%) of the Down's syndrome patients were treated with once daily administration of insulin, the mean HbA1c value of the group was similar to that observed in a control group of 39 age-, sex- and duration-matched Type 1 patients, all of whom were taking two or more injections of insulin daily. Glycaemic control was therefore of similar quality to matched Type 1 patients without Down's syndrome, despite the frequent use of simple insulin regimens, which may relate to the more stable lifestyle of these patients.
1型胰岛素依赖型糖尿病（1型糖尿病）被认为在唐氏综合征患者中更为普遍。为了确定在一个地理区域内唐氏综合征患者中1型糖尿病的当地患病率，对洛锡安地区的四家糖尿病诊所进行了调查，共识别出13名患有唐氏综合征和1型糖尿病的患者。利用先前流行病学调查的数据确定了普通人群中唐氏综合征的患病率，计算出唐氏综合征患者中1型糖尿病的患病率在1.4%至10.6%之间，该患病率明显高于普通人群。尽管7名（54%）唐氏综合征患者接受了每日一次胰岛素注射治疗，但该组的平均糖化血红蛋白（HbA1c）值与一组年龄、性别和病程匹配的39名1型糖尿病对照患者相似，这些对照患者均每天注射两次或更多次胰岛素。因此，尽管经常使用简单的胰岛素治疗方案，但血糖控制质量与无唐氏综合征的匹配1型患者相似，这可能与这些患者更稳定的生活方式有关。
