Fulcher T, Griffin M, Crowley S, Firth R, Acheson R, O'Meara N
Department of Ophthalmology, Mater Misericordiae Hospital, Dublin, Ireland.
Br J Ophthalmol. 1998 Apr;82(4):407-9. doi: 10.1136/bjo.82.4.407.
To determine the prevalence of diabetic retinopathy in patients with Down's syndrome and diabetes mellitus.
Nine patients with Down's syndrome and diabetes mellitus were assessed. Factors recorded included type and duration of diabetes, level of diabetic control, blood pressure, urinalysis, and results of ophthalmological examination.
The duration of diabetes ranged from 8 to 41 years (mean 17.6 years). All had satisfactory glycaemic control and blood pressure measurements on the low side of normal (mean 106.6/70 mm Hg). One patient had early background diabetic retinopathy. The remainder had no evidence of diabetic retinopathy.
The low prevalence of diabetic retinopathy in these Down's syndrome patients, despite the long duration, is an interesting finding. It suggests some inherent protective factor against the development of diabetic retinopathy in this patient subgroup.
确定唐氏综合征合并糖尿病患者糖尿病视网膜病变的患病率。
对9例唐氏综合征合并糖尿病患者进行评估。记录的因素包括糖尿病类型和病程、糖尿病控制水平、血压、尿液分析及眼科检查结果。
糖尿病病程为8至41年（平均17.6年）。所有患者血糖控制良好，血压测量值处于正常范围较低水平（平均106.6/70 mmHg）。1例患者有早期背景性糖尿病视网膜病变。其余患者无糖尿病视网膜病变证据。
尽管病程较长，但这些唐氏综合征患者糖尿病视网膜病变患病率较低，这是一个有趣的发现。这表明在该患者亚组中存在某种内在的保护因素，可防止糖尿病视网膜病变的发生。
