Yoneyama T, Ishihara K, Nakabayashi N, Ito M, Mishima Y
Second Department of Surgery, Tokyo Medical and Dental University School of Medicine, Japan.
J Biomed Mater Res. 1998 Spring;43(1):15-20. doi: 10.1002/(sici)1097-4636(199821)43:1<15::aid-jbm2>3.0.co;2-p.
A small-diameter vascular prosthesis with potential for clinical use was prepared from a Dacron prosthesis coated with nonthrombogenic polymeric materials. As a coating material, segmented poly(etherurethane) (SPU; Tecoflex 60) was blended with a phospholipid polymer, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, which has excellent blood compatibility. The Dacron prosthesis, 2 mm in diameter, was immersed in a solution of the SPU/MPC polymer blend and dried to evaporate the solvent. The SPU/MPC polymer prosthesis was nonwater permeable and could be sewn to a natural vessel by a microsurgical technique. The SPU solution was used instead of the SPU/MPC polymer blend solution to prepare a control prosthesis (SPU prosthesis). The SPU/MPC polymer prosthesis and the SPU prosthesis were placed as interposition grafts in rabbit carotid arteries. A massive red thrombus became attached to the surface of the SPU prosthesis as early as 90 min after implantation. In the SPU/MPC polymer prosthesis case, the surface was maintained clear even after 5-day implantation. These observations indicated that the MPC polymer in the SPU could improve the nonthrombogenicity of SPU, and the SPU/MPC polymer blend had potential for preparation of small-diameter vascular prostheses.
一种具有临床应用潜力的小直径血管假体，是由涂覆了抗血栓形成聚合物材料的涤纶假体制备而成。作为涂层材料，将嵌段聚（醚氨酯）（SPU；泰科弗莱克斯60）与具有优异血液相容性的磷脂聚合物2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）聚合物混合。将直径为2毫米的涤纶假体浸入SPU/MPC聚合物共混物溶液中，干燥以蒸发溶剂。SPU/MPC聚合物假体不透水，可通过显微外科技术缝合到天然血管上。使用SPU溶液代替SPU/MPC聚合物共混物溶液制备对照假体（SPU假体）。将SPU/MPC聚合物假体和SPU假体作为插入移植物植入兔颈动脉。早在植入后90分钟，大量红色血栓就附着在SPU假体表面。在SPU/MPC聚合物假体的情况下，即使在植入5天后表面仍保持清洁。这些观察结果表明，SPU中的MPC聚合物可以改善SPU的抗血栓形成性，并且SPU/MPC聚合物共混物具有制备小直径血管假体 的潜力。
