Hazar V, Kutluk T, Akyüz C, Varan A, Yariş N, Büyükpamukçu M
Department of Pediatric Oncology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Pediatr Hematol Oncol. 1998 Jan-Feb;15(1):85-9. doi: 10.3109/08880019809009513.
We report two pediatric cases who developed veno-occlusive disease-like hepatotoxicity while receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed. Other possible causes of hepatotoxicity were excluded. Recovery was observed with supportive therapy after 2 and 1 weeks, respectively. After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs. We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.
我们报告了两例儿科病例，这两名患儿在接受针对肾母细胞瘤和肾透明细胞肉瘤的化疗时出现了类似肝静脉闭塞性疾病的肝毒性。在出现肝毒性之前，第1例患儿接受了长春新碱、放线菌素D和表柔比星化疗，第2例患儿接受了长春新碱和放线菌素D化疗。肝毒性的其他可能原因均被排除。分别在2周和1周后，通过支持治疗观察到患儿康复。康复后，患儿能够耐受继续化疗，且药物剂量未减少。我们得出结论，长春新碱和放线菌素D是这种罕见肝毒性的病因，并且在临床康复后可以安全地继续对潜在恶性疾病进行化疗。
