Wolfe-Coote S A, Louw J, Woodroof C W, Heydenrych J J, du Toit D F
Experimental Biology Programme, Medical Research Council, Cape Town, South Africa.
Pancreas. 1998 Mar;16(2):129-33. doi: 10.1097/00006676-199803000-00004.
Cellophane wrapping of the adult Syrian golden hamster pancreas has been found to result in ductular cell proliferation leading to islet regeneration. Injection of cytosol from a cellophane-wrapped pancreas into normal or diabetic hamsters evoked a similar response. In view of the therapeutic potential of the active substance in this cytosol, it was decided to investigate whether a similar response could be achieved in a primate. In normal adult Vervet monkey (Cercopithecus aethiops) pancreas, proliferation is seen only rarely in islet cells and occasionally in duct and acinar cells. Immunohistochemical investigation of normal Vervet monkey pancreas (n = 4) and 14 days (n = 2) and 56 days (n = 1) after cellophane wrapping of the Vervet monkey pancreas revealed a slight increase in proliferation of islet and acinar cells and a larger increase in proliferation of duct cells and in total endocrine cell volume. The results suggest that there is a latent developmental capability in the adult primate pancreas.
已发现用玻璃纸包裹成年叙利亚金黄地鼠的胰腺会导致导管细胞增殖，进而引发胰岛再生。将来自用玻璃纸包裹的胰腺的胞质溶胶注射到正常或糖尿病仓鼠体内会引发类似反应。鉴于这种胞质溶胶中活性物质的治疗潜力，决定研究在灵长类动物中是否能实现类似反应。在正常成年绿猴（猕猴属埃塞俄比亚种）的胰腺中，仅在胰岛细胞中很少见到增殖，偶尔在导管和腺泡细胞中可见。对正常绿猴胰腺（n = 4）以及绿猴胰腺用玻璃纸包裹后14天（n = 2）和56天（n = 1）进行免疫组织化学研究发现，胰岛和腺泡细胞的增殖略有增加，导管细胞的增殖以及总内分泌细胞体积有更大幅度的增加。结果表明成年灵长类动物胰腺存在潜在的发育能力。
