Luna B, Thulborn K R, Strojwas M H, McCurtain B J, Berman R A, Genovese C R, Sweeney J A
Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, PA, USA.
Cereb Cortex. 1998 Jan-Feb;8(1):40-7. doi: 10.1093/cercor/8.1.40.
Neurophysiological studies in non-human primates have identified saccade-related neuronal activity in cortical regions including frontal (FEF), supplementary (SEF) and parietal eye fields. Lesion and neuroimaging studies suggest a generally homologous mapping of the oculomotor system in humans; however, a detailed mapping of the precise anatomical location of these functional regions has not yet been achieved. We investigated dorsal frontal and parietal cortex during a saccade task vs. central fixation in 10 adult subjects using functional magnetic resonance imaging (fMRI). The FEF were restricted to the precentral sulcus, and did not extend anteriorly into Brodmann area 8, which has traditionally been viewed as their location in humans. The SEF were located in cortex along the interhemispheric fissure and extended minimally onto the dorsal cortical surface. Parietal activation was seen in precuneus and along the intraparietal sulcus, extending into both superior and inferior parietal lobules. These findings localize areas in frontal and parietal cortex involved in saccade generation in humans, and indicate significant differences from the macaque monkey in both frontal and parietal cortex. These differences may have functional implications for the roles these areas play in visuomotor processes.
对非人类灵长类动物的神经生理学研究已经在包括额叶眼区（FEF）、辅助眼区（SEF）和顶叶眼区在内的皮质区域中识别出与扫视相关的神经元活动。病变和神经影像学研究表明，人类眼球运动系统存在大致同源的映射；然而，尚未实现对这些功能区域精确解剖位置的详细映射。我们使用功能磁共振成像（fMRI）对10名成年受试者在扫视任务与中央注视期间的背侧额叶和顶叶皮质进行了研究。额叶眼区局限于中央前沟，并未向前延伸至传统上被认为是其在人类中位置的布罗德曼第8区。辅助眼区位于沿大脑半球间裂的皮质中，并最小程度地延伸至背侧皮质表面。在楔前叶和沿顶内沟观察到顶叶激活，延伸至顶叶上小叶和下小叶。这些发现确定了人类额叶和顶叶皮质中参与扫视产生的区域，并表明在额叶和顶叶皮质方面与猕猴存在显著差异。这些差异可能对这些区域在视觉运动过程中所起的作用具有功能意义。
