Grigorenko D e, Erofeeva L M, Sapin M R
Laboratory of Functional Anatomy, Russian Academy of Medical Sciences, Moscow.
Morfologiia. 1997;112(6):53-7.
Quantitative study of thymus and spleen cytoarchitectonics performed in mice one day after gamma irradiation revealed peculiarities of response of certain morphological zones of the organs along with common changes of the organ cellular composition (lymphocytopenia, destructive processes intensification, granulocyte reaction and decrease of mitotic activity). In thymus changes of cytoarchitectonics of cortical substance (especially in subcapsular zone) are connected with sharp intensification of cell destruction, which implicates lymphocyte loss and with complete suppression of cell mitotic activity and differentiation, with medullar substance of thymus being the most stable structure in cellular composition. Lymphoid nodules without germinal centres, cytoarchitectonics of which, despite certain changes to greater extent resembles control indexes, can be considered the most stable structure in spleen, where irradiation completely suppresses germinal centres of lymphoid nodules. Red pulp appeares to be more labile zone in the organ and its architectonics is mostly subjected to alteration in irradiation.
对γ射线照射后一天的小鼠进行胸腺和脾脏细胞结构的定量研究，结果显示这些器官特定形态区域的反应具有特殊性，同时器官细胞组成也有共同变化（淋巴细胞减少、破坏过程加剧、粒细胞反应以及有丝分裂活性降低）。在胸腺中，皮质物质（尤其是被膜下区）的细胞结构变化与细胞破坏的急剧加剧有关，这意味着淋巴细胞丢失，同时细胞有丝分裂活性和分化完全受到抑制，而胸腺髓质物质在细胞组成方面是最稳定的结构。无生发中心的淋巴小结，其细胞结构尽管有一定变化，但在很大程度上更接近对照指标，可被认为是脾脏中最稳定的结构，在脾脏中照射完全抑制了淋巴小结的生发中心。红髓似乎是该器官中更不稳定的区域，其结构在照射后大多会发生改变。
