Grigorenko D Ye
Morfologiia. 2015;148(4):19-23.
The changes of the cellular composition of splenic lymphoid tissue were studied 7, 15 and 30 days after irradiation with a dose of 50 rad, in BALB/c mice which received either distilled water or light (deuterium-depleted) water for a long time prior to and after irradiation. The irregular pattern of changes of splenic cellular composition was observed during the experiment. It was found that at day 7 after irradiation, the splenic structural zones in mice demonstrated a sharp decrease in the number of blast forms and mitotic cells, reflecting a lower level of lymphocytopoiesis, as well as an increased cellular destruction in mice consuming light water. By day 30 of the experiment, different responses of lymphoid structures were observed in the organ. In the periarteriolar lymphoid sheaths, the processes of cellular composition regeneration were more pronounced than in the germinal centers of lymphoid nodules, indicating the enhancement of body cell-mediated immunity and immunomodulating properties of light water in mice at later dates of post-irradiation period.
在BALB/c小鼠中，研究了在照射剂量为50拉德后7天、15天和30天脾脏淋巴组织细胞组成的变化。这些小鼠在照射前后长时间分别饮用蒸馏水或轻水（贫氘水）。实验期间观察到脾脏细胞组成的变化模式不规则。结果发现，照射后第7天，饮用轻水的小鼠脾脏结构区的母细胞和有丝分裂细胞数量急剧减少，这反映淋巴细胞生成水平较低，同时细胞破坏增加。到实验第30天，在该器官中观察到淋巴结构的不同反应。在动脉周围淋巴鞘中，细胞组成的再生过程比在淋巴小结的生发中心更明显，这表明在照射后后期，轻水增强了小鼠的机体细胞介导免疫和免疫调节特性。
