2-巯基-N-（唑基）苯磺酰胺。IV. 某些具有潜在抗癌和抗HIV活性的4-氯-2-巯基-5-甲基-N-（苯并咪唑-2-基）苯磺酰胺衍生物的合成
2-Mercapto-N-(azolyl)benzenesulphonamides. IV. Syntheses of some 4-chloro-2-mercapto-5-methyl-N-(benzimidazol-2-yl)benzenesulph onamide derivatives with potential anticancer and anti-HIV activities.
作者信息
Pomarnacka E, Brzozowski Z
机构信息
Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
出版信息
Acta Pol Pharm. 1997 May-Jun;54(3):215-21.
PMID:9511447
Abstract
Syntheses of 4-chloro-2-mercapto-5-methyl-N-(5-R1-6-R2-benzimidazol-2-yl) benzenesulphonamides [II-V], their disulfides [IIa-IVa] and S,N-substituted derivatives [VI-IX] were described. The probable mechanism for the reactions was suggested. The moderate anticancer activity was observed in vitro for compounds [II-IV].
摘要
描述了4-氯-2-巯基-5-甲基-N-(5-R1-6-R2-苯并咪唑-2-基)苯磺酰胺[II-V]、它们的二硫化物[IIa-IVa]以及S,N-取代衍生物[VI-IX]的合成。提出了反应的可能机理。观察到化合物[II-IV]在体外具有适度的抗癌活性。
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