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Syntheses of S,N-substituted 2-mercaptobenzenesulfonamide derivatives with potential pharmacological activity.

作者信息

Pomarnacka E, Kornicka A

机构信息

Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.

出版信息

Acta Pol Pharm. 1998 Jul-Aug;55(4):297-304.

PMID:9821395
Abstract

A series of [5-chloro-4-methyl-2-sulfamoylphenyl(thio or sulfonyl)]alkanoic acids [I-VI], their methyl esters [VII-XII] and hydrazides [XIII-XXI] were prepared. The treatment of the selected esters [VII-VIII, XI-XII] with appropriate biguanide hydrochlorides gave 4-chloro-5-methyl-2-[2-amino-6-R3-triazin-4-ylalkyl(thio or sulfonyl)]benzenesulfonamides [XXII-XXVII]. The anticancer activity was observed in vitro for compound [XXII].

摘要

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