2-Mercapto-N-(azolyl)benzenesulphonamides. II. Syntheses, anti-HIV-1 and anticancer activity of some S-substituted 4-chloro-2-mercapto-5-methyl-N-(5-amino-1,2,4-triazol-3-yl) benzenesulphonamides.

The 4-chloro-2-mercapto-5-methyl-N-[5-R1-amino-S-triazol-3-yl] benzenesulphonamides (I-III; R1 = H, Ph or 3-MeOPh) were converted into S-substituted derivatives IV-XIV as potential anti-HIV-1 and/or anticancer agents. Preliminary screening data of compounds [IV-V, VII-XI] and [XIV] indicate that some of them exhibit weak anticancer activity [IV and XI] and moderate anti-HIV-1 activity [IV]. Some structure-activity relationships are also discussed.