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[节段性丝裂霉素明胶微球/脂质体经动脉化疗栓塞术与节段性丝裂霉素明胶微球/脂质体经动脉化疗灌注术治疗肝细胞癌的抗肿瘤活性及副作用的比较研究]

[Comparative studies on the antitumor activities and side effects of segmental SMANCS/Lip-TAE with segmental SMANCS/Lip-TAI for hepatocellular carcinoma].

作者信息

Matoba M, Okimura T, Yamamoto I

机构信息

Dept. of Radiology, Kanazawa Medical University.

出版信息

Gan To Kagaku Ryoho. 1998 Feb;25 Suppl 1:73-9.

PMID:9512692
Abstract

We compared the effectiveness of treatments and the influence of side effects on liver function and clinical symptoms between segmental SMANCS/ Lip TAI and segmental SMANCS/Lip-TAE. The early tumor response rate of the group treated by TAI was 23.6%, and that of the group treated by TAE was 80.0%. In the group treated by TAE, the therapeutic effects were better in the nodular type than in the diffuse type of HCC, and we were also able to obtain a good tumor response rate on the multiple HCC and large HCC. However, there was no difference in the response period between the groups treated by TAI and TAE. In both groups, there were no significant differences in the appearance rate and degree of side effects. In conclusion, segmental SMANCS/Lip-TAE seemed to be an effective treatment for HCC without any serious complications.

摘要

我们比较了节段性丝裂霉素超液化碘油化疗栓塞术(SMANCS/Lip TAI)与节段性丝裂霉素超液化碘油肝动脉栓塞术(SMANCS/Lip-TAE)在治疗效果以及副作用对肝功能和临床症状的影响方面的差异。经肝动脉灌注化疗(TAI)组的早期肿瘤反应率为23.6%,经肝动脉栓塞术(TAE)组为80.0%。在TAE组中,结节型肝癌的治疗效果优于弥漫型,对于多发肝癌和大肝癌我们也能获得较好的肿瘤反应率。然而,TAI组和TAE组之间在反应期方面没有差异。两组在副作用的发生率和程度上均无显著差异。总之,节段性SMANCS/Lip-TAE似乎是一种治疗肝癌的有效方法,且无任何严重并发症。

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