梭柄松萝酸，一种来自担子菌纲真菌梭柄松萝的三萜类真核生物DNA聚合酶抑制剂。
Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea.
作者信息
Tanaka N, Kitamura A, Mizushina Y, Sugawara F, Sakaguchi K
机构信息
Department of Applied Biological Science, Science University of Tokyo, Japan.
出版信息
J Nat Prod. 1998 Feb;61(2):193-7. doi: 10.1021/np970127a.
PMID:9514006
Abstract
Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determined by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with respective minimum inhibitory concentration (MIC) ranges of 35-75 and 90-130 microM.
摘要
从担子菌亚门真菌黄多孔菌的菌丝体中分离出四种新的三萜类化合物1-4，并通过光谱分析确定了它们的结构。化合物1-5抑制小牛DNA聚合酶α和大鼠DNA聚合酶β，其最低抑菌浓度（MIC）范围分别为35-75和90-130微摩尔。
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