五味子酸，一种来自华中五味子的三萜类化合物，可抑制HIV-1逆转录酶。
Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.
作者信息
Sun H D, Qiu S X, Lin L Z, Wang Z Y, Lin Z W, Pengsuparp T, Pezzuto J M, Fong H H, Cordell G A, Farnsworth N R
机构信息
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.
出版信息
J Nat Prod. 1996 May;59(5):525-7. doi: 10.1021/np960149h.
An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.
从中国传统药用植物华中五味子的茎中分离出一种A环-裂环环阿尔廷型三萜类化合物——黑蔓酸（3,4-裂环环阿尔廷-4(28),24-(Z)-二烯-3,26-二酸，(1)）。借助计算机模拟，通过一维和二维核磁共振技术相结合的方法完成了其结构解析及明确的核磁共振光谱归属。黑蔓酸在几种抗HIV逆转录酶和聚合酶检测中显示出活性。
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