Eze A R, Cisek P L, Holland B S, Comerota A J, Verramasuneni R, Comerota A J
Carolinas Medical Center, Charlotte, North Carolina, USA.
Ann Vasc Surg. 1998 Mar;12(2):182-6. doi: 10.1007/s100169900138.
Intermittent lower extremity compression increases cutaneous blood flow. The source of this increased perfusion and, the influence of physical activity on stimulated foot skin perfusion has not been elucidated. The purpose of this study is to determine the arterial and venous contributions to augmented cutaneous blood flow during foot and leg compression, and to evaluate whether physical activity influenced the response to compression. Fifty limbs from 29 normal volunteers were studied in the sitting position. Their daily physical activity was categorized as active if they exercised > or =3 days/week or sedentary if they exercised < or =3 days/week. Inflatable foot and calf compression cuffs attached to a timed-pressure pump (Art-assist AA 1000, ACI, Inc., San Marcos, CA) were applied to the subject's leg and set to deliver 120 mmHg pressure with a 10-sec deflation cycle. Skin perfusion of the great toe was recorded by a laser Doppler (Laserflo Model BPM 403, TSI, Inc., St. Paul, MN). Total perfusion with compression (A), retrograde venous perfusion (B), and compression artifact (C) was recorded. Mean values for A, B, and C and the differences between the two groups were analyzed using multivariate multiple comparison statistical method. The mean baseline skin perfusion was 3.96 +/- 0.91, and mean total stimulated skin perfusion (A) was 9.23 +/- 2.13. With arterial inflow obliterated and compression applied, mean skin perfusion (B) was 1.96 +/- 0.44. The sedentary group had a mean resting perfusion of 1.64 +/- 0.28 and mean stimulated value (A) of 2.29 +/- 0.37 ml/min/100 gm tissue. The active group had a mean resting perfusion of 28.26 +/- 0.91, and stimulated value (A) of 32.65 +/- 4.47 ml/min/100 gm tissue. These differences in the mean skin perfusion between the two groups were significant. It is concluded that in normals, the majority of increased perfusion is from increased arterial inflow. There is a larger resting foot skin perfusion in active individuals and they have quantitatively greater stimulated inflow compared to sedentary individuals.
间歇性下肢压迫可增加皮肤血流。这种灌注增加的来源以及身体活动对受刺激的足部皮肤灌注的影响尚未阐明。本研究的目的是确定在足部和腿部受压期间动脉和静脉对皮肤血流增加的贡献，并评估身体活动是否影响对压迫的反应。对29名正常志愿者的50条肢体进行了坐位研究。如果他们每周锻炼≥3天，则将其日常身体活动分类为活跃；如果他们每周锻炼≤3天，则分类为久坐不动。将连接到定时压力泵（Art-assist AA 1000，ACI公司，加利福尼亚州圣马科斯）的充气式足部和小腿压迫袖带应用于受试者的腿部，并设置为以10秒放气周期输送120 mmHg压力。通过激光多普勒仪（Laserflo型号BPM 403，TSI公司，明尼苏达州圣保罗）记录大脚趾的皮肤灌注。记录压迫时的总灌注量（A）、逆行静脉灌注量（B）和压迫伪像（C）。使用多变量多重比较统计方法分析A、B和C的平均值以及两组之间的差异。平均基线皮肤灌注为3.96±0.91，平均总刺激皮肤灌注（A）为9.23±2.13。在阻断动脉血流并施加压迫的情况下，平均皮肤灌注（B）为1.96±0.44。久坐不动组的平均静息灌注为1.64±0.28，平均刺激值（A）为2.29±0.37 ml/分钟/100克组织。活跃组的平均静息灌注为28.26±0.91，刺激值（A）为32.65±4.47 ml/分钟/100克组织。两组之间平均皮肤灌注的这些差异具有显著性。结论是，在正常人中，大部分灌注增加来自动脉血流增加。活跃个体的静息足部皮肤灌注较大，与久坐不动的个体相比，他们的刺激流入量在数量上更大。
